Banca de QUALIFICAÇÃO: LUCAS FRANÇA DE BARROS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : LUCAS FRANÇA DE BARROS
DATA : 27/10/2023
HORA: 18:00
LOCAL: Sala Virtual - Google Meet
TÍTULO:

Distribution of Blastocystis spp. in different environments in Mato Grosso state: an ecological and epidemiological approach

PALAVRAS-CHAVES:

Protozoology, Environmental Sciences, Systematic Review, Molecular Biology

PÁGINAS: 85
GRANDE ÁREA: Outra
ÁREA: Ciências Ambientais
RESUMO:

Blastocystis spp. is an anaerobic enteric protozoan without flagella, belonging to the class Blastocystea, found in a wide variety of animals, including humans. Transmission occurs via the fecal-oral route, with contamination of water and food being a source of infection. The commensal or pathogenic nature of this parasite is the subject of debate, as it can be found both in healthy people and in patients with intestinal symptoms, such as diarrhea and irritable bowel syndrome. It is estimated that around one billion people are infected by the pathogen, linked to basic sanitation conditions and contact with infected animals. The geographic distribution of Blastocystis spp. varies, reaching up to 65% of infections in different regions, with a higher prevalence in developing countries. The association between Blastocystis spp. and intestinal diseases, such as irritable bowel syndrome (IBS), is a matter of debate, as the protozoan is found in both healthy people and patients with intestinal symptoms. This project aimed to investigate the distribution and prevalence of Blastocystis spp., in different hosts and classes, in different environments in Mato Grosso state. To analyze the collected samples, the Hoffman technique or, as also known, the spontaneous sedimentation technique, was used. As a result, we obtained two articles, one analyzing the samples and the other a global review. As detailed in article one, a worldwide systematic review of Blastocystis spp. subtypes was performed. found in animals and humans. This review revealed a diversity of subtypes (STs) of Blastocystis spp., with some being more prevalent in humans, such as ST1 to ST4 and ST7. These subtypes have also been found in animals, suggesting zoonotic transmission. Animal-unique subtypes such as ST10 to ST17 have also been identified. The geographic distribution of subtypes of Blastocystis spp. is not homogeneous, varying regionally. Analysis of genetic sequences revealed distribution patterns by continent. The diversity of hosts, including mammals, birds, reptiles and insects, contributes to the global spread of Blastocystis spp. Future research should focus on understanding the biological behaviors of this parasite, epidemiological studies in diverse regions and hosts for a more complete picture of its epidemiology, and comparative genomic studies for better understanding. In article two, a study on the prevalence and distribution in different biomes and types of animals in Mato Grosso state highlighted high infection rates, with variations between domestic, farmed and wild animals, influenced by humidity, water availability and habitat characteristics. These results emphasize the importance of considering regional factors in understanding the dynamics of Blastocystis spp. infection. in Mato Grosso state.

MEMBROS DA BANCA:
Presidente - 61265003 - ANTONIO FRANCISCO MALHEIROS
Interno - 65536013 - CLAUMIR CESAR MUNIZ
Interno - 118188003 - ERNANDES SOBREIRA OLIVEIRA JUNIOR
Externo à Instituição - ALEXSANDRA RODRIGUES DE MENDONÇA FAVACHO - Fiocruz - RJ